Abstract: To address the heat dissipation challenge in aerospace and electronics, this paper undertakes liquid cooling experiments utilizing a novel multi-orifice dual synthetic jets actuator (MODSJA). The performance of the DSJ-based liquid cooling device and the associated flow fields are thoroughly analyzed, considering the effects of various parameters, including heat flux, channel inlet flow rate, and driving frequency. Results indicate that the wall temperature of the device increases with increasing heat flux. When DSJ is on, the wall temperature decreases; otherwise, the wall temperature reduction can be also achieved by increasing the inlet flow rate, but at the price of remarkable pressure drops. This is because the higher the flow rate, the faster the fluid carries away heat, resulting in a temperature drop. When the actuator is activated at a flow rate of 0.16 L/min, the wall temperature is reduced by 3.07 ℃, which is comparable to that achieved with an inlet flow rate of 0.4 L/min when the actuator is off, indicating at least a 583.08% reduction in pump power requirement without causing an increase in pressure drop. Within the frequency range under investigation, the DSJ liquid cooling device achieves an optimal performance at 20Hz, yielding a wall temperature decrease of 3.80 ℃ and a marginal increase of 0.03 kPa in the pressure drop. Moreover, a higher driving voltage results in a more pronounced wall temperature drop, achieving a maximum reduction of 4.16 ℃ at 240 V. In summary, the experimental results clearly show that DSJ can achieve significant heat dissipation with a negligible increase in pressure drop, thus making it a promising solution for heat management in aerospace and electronic applications.