Abstract: This paper briefly analyzes the advantage of Modem Design of Experiments (MDOE) contrast to One Factor At a Time (OFAT) test method, and tries to find the key influence factors of MDOE. A new design method of experiments is presented based on aerodynamic models. The research shows that aerodynamic model is one of the key elements of MDOE. In order to prove that, this paper first gives a common trigonometric series model for a kind of axial symmetry vehicle with electrical cable cover. Then, taking a certain flight vehicle as an example, this paper researches the effects of trigonometric series and response surface aerodynamic models on MDOE, according to saturation D-optimal rule. This research shows that aerodynamic model play an important role in MDOE and the new design method of experiments is effective. Some valuable conclusions have been reached.