Abstract: The gas-kinetic scheme (GKS) is expanded and applied in modeling the supersonic flow past re-entry vehicles with complex flow phenomena such as rarefied effect and turbulence. The GKS utilizes the general solution of the BGK equation to obtain the time evolving flux at the cell interface, coupling particle free transport and collisions, thus with inherent multiscale characteristics. In this work, based on the expanded BGK equation typical turbulence models are included in the GKS to effectively simulate typical supersonic turbulence with high Reynolds number. Based on the CPR, a high-order GKS on unstructured grid is developed for compressible viscous flows with capability to accurately capture shocks. To simulate the rarefied re-entry flow, high performance parallel algorithm for the UGKS is developed. These studys show the good performance of the GKS in re-entry flows and its good prospect for wide applications.