Abstract: This paper proposes a new design method for aircrafts with flying-wing layouts. Aerodynamic characteristics and design requirements of flying-wing layouts are firstly analyzed. Aerodynamic design requirements for different spanwise partitions of flying wings are then put forward for the design of partitioned airfoils. Since traditional airfoil design methods do not take the cross-flow effect into account, their applications in designing three-dimensional airfoil layouts cannot achieve desired performance. Consequently, a global/local airfoil multidisciplinary design method is proposed. According to aerodynamic design requirements of flying wings, an efficient proxy model based on partitioned airfoils for global optimization design and a refined local optimization design method for three-dimensional layouts are established and integrated. This multi-disciplinary collaborative global/local optimization method can quickly realize the airfoil design that meets the performance requirements of multi-section flying wing layouts, and can effectively improve the performance and design efficiency of designed airfoils. Finally, the reliability of this method is verified by an airfoil design process based on the X47-B layout.