Abstract: Taking Taihong Yangtze River Bridge as an example, the buffeting response of the bridge under non-Gaussian wind field is studied. Firstly, based on Hermite polynomial model, the time history of the non-Gaussian fluctuating wind field is simulated. Subsequently, the corresponding wind load time history is calculated, and the time domain analysis of the buffeting response of the bridge is carried out. Finally, by comparing the response results of fluctuating wind fields with different non-Gaussian characteristics under various mean wind speeds, the influence of non-Gaussian characteristics of wind field on the buffeting response of the bridge structure is discussed. The results show that the amplitude and root mean square (RMS) of the buffeting response under non-Gaussian wind field are larger than the counterparts under Gaussian wind field, and stronger non-Gaussian characteristics correspond to larger RMS. With the increase of mean wind speed, the influence of kurtosis of the wind field on the RMS of the response becomes more obvious. Therefore, the Gaussian process assumption underestimates the actual response of a non-Gaussian wind field. In addition, the skewness and kurtosis of the buffeting response under fluctuating wind field with different non-Gaussian characteristics are similar to the results of the Gaussian process.