Abstract: To ensure the relative spatial stability of test models in wind tunnels, this study proposes a novel position and attitude control algorithm incorporating aerodynamic interference compensation for magnetic suspension and balance system (MSBS). Aerodynamic drag characteristics of the test model were first obtained through computational fluid dynamics simulations. A dynamic model of the axial suspension system was subsequently established, and a nominal dual-loop feedback controller was also designed. To achieve real-time and accurate estimation of aerodynamic disturbances, a prior model-based disturbance estimation strategy was developed. Furthermore, to overcome the instability of the nominal controller in supersonic wind tunnels, an enhanced control strategy integrating aerodynamic interference compensation into the axial system of MSBS was proposed and validated through numerical simulations. Additionally, a wind tunnel aerodynamic resistance simulation platform was constructed for experimental verification. Comparative experimental results demonstrate that the proposed control strategy exhibits superior robustness against aerodynamic disturbances compared to active disturbance rejection control.