Abstract: Due to the close proximity of super high-rise buildings in densely populated urban centers, the significant impact of wind-induced interference on adjacent structures must be taken into consideration. Previous research did not employ two aeroelastic models to investigate the wind-induced interference effect between two adjacent super-tall buildings. As a result, the aeroelastic effect and wind-induced interference effect could not be well reflected. In this paper, based on a series of two-aeroelastic-model wind tunnel experiments, the aerodynamic interference effect of the across-wind response of two adjacent square high-rise buildings is studied. The influences of interference location, reduced wind speed, dynamic characteristics, and model type on the aerodynamic interference factors of across-wind acceleration response are analyzed. The wind tunnel experiments were conducted at 35 interference locations, with 18 reduced wind speeds tested at each location, and contour maps of the interference factors were obtained as a result. Subsequently, wind tunnel experiments are performed on a one-rigid-one-aeroelastic building model at typical interference locations. Upon comparing the results of two kinds of wind tunnel experiments, it was found that the aeroelastic effect increases the absolute negative aerodynamic damping of disturbed buildings at medium and high wind speeds, and the interference factor also increases. Neglecting the aerodynamic effect of disturbing buildings can bias the evaluation results of wind-induced response towards danger.