Abstract: After decades of studies, the potentialities of traditional wingbody configuration are almost exhausted. So, it is difficult to improve the performance of the traditional aerodynamic shape of transonic civil aircraft by conventional design method. In this paper we develop ADJOINT method based on aerodynamics optimization software ADJOPT, and the software is used to optimize the wing of a transonic civil aircraft with fuselage and nacelle, which is already optimized by traditional way. The optimization is multiparameter, high precise and taking the influence of the fuselage and nacelle into account. The software performs well and gets obvious performance improvement. The research shows that multiparameter optimization has the ability to exploit potentialities of a highperformance shape and increases the aerodynamic performance of it.