Abstract: A Multi-Point/Objective Optimization design approach of high lift-to-drag ratios for Natural Laminar Airfoils is developed.XFOIL code is used to calculate pressure distribution to reduce the computation cost.The numerical optimization is based on Response Surface Methodology and the RS model is reduced quadratic polynomials without the 2-order cross items to reduce the experiment times in constructing RS models.The set of candidate design points in design space is selected to satisfy D-optimality.Multi Point/Objective designs are performed based on the analysis of Single-Point/Objective design results.The results indicate that Multi-Point/Objective design improves the overall performance of the design with respect to the Single-Point design.