Abstract: The multi-physical effects at high attitude and high Mach number have significant influences on aerodynamic performance of hypersonic gliding waverider. The present research generated a typical gliding waverider vehicle from a conederived waverider through engineering design. The influences of multiphysical effects on aerodynamic performance was analyzed by CFD method. Viscous interaction effects and real gas effects on the hypersonic gliding vehicle were studied respectively. In addition, inviscid and viscous CFD method based on perfect gas, as well as viscous CFD method based on equilibrium gas were applied to investigate the sensitivity of each physical effects (including Mach number effects, viscous interaction effects and real gas effects) on different aerodynamic parameters. Results of this study indicate that variations of aerodynamic parameters influenced by different physical effects are of great difference, so just one or two physical effects could be concerned while designing a hypersonic gliding vehicle. The results are valuable for the design and aerodynamic estimation of hypersonic gliding waverider vehicles.